Rx Note

Introduction Dental caries (tooth decay) is a pathological process resulting in localised destruction of tooth tissue. Dental plaque (a complex biofilm of mixed bacteria and their by-products) is a prerequisite for dental caries development. Frequent exposure to dietary sugar and carbohydrates leads to an increase in the population of cariogenic bacteria in the biofilm. Cariogenic bacteria produce organic acids, which lower the pH of the biofilm, resulting in enamel demineralisation (loss of carbonated hydroxyapatite). NOTE:  Dental caries can often progress without noticeable signs of deep or large cavities. To prevent further deterioration, it is advisable to consult a dentist as soon as you experience sensitivity to hot or cold temperatures, rather than waiting for more severe pain. Fluoride-containing Toothpaste Use of fluorides is the primary means of preventing dental caries across all age groups . Fluoride promotes enamel remineralisation through the formation of fluoride-c...

Drug Safety Update In 2014, the European Medicines Agency (EMA) reviewed the safety of domperidone-containing products due to its association with the risk of serious and potentially life-threatening cardiovascular adverse effects such as ventricular arrhythmias and sudden cardiac death. In 2019, a randomised controlled study showed that the use of domperidone in children below 12 years of age with acute gastroenteritis (in combination with oral rehydration therapy) showed no difference in efficacy when compared to placebo. As a result, domperidone is no longer indicated for the relief of nausea and vomiting in children aged under 12 years. Recommendations Healthcare professionals are advised to adhere to the licensed dose and to use the lowest effective dose for the shortest possible duration (maximum treatment duration should not usually exceed 1 week). Moreover, domperidone is contraindicated in Patients with known existing prolongation of cardiac conduction intervals; Patients ...