Rx Note

Introduction Rheumatoid arthritis is a chronic autoimmune disease characterized by persistent synovitis, systemic inflammation and the presence of autoantibodies. Persistent joint inflammation can lead to the development of bony erosions, cartilage and tendon degradation and joint deformity. It usually affects the small joints of hands, wrists and feet, but can also occurs at other sites. It is more common in females than males, with onset between the ages of 30 and 60 years. Features suggesting rheumatoid arthritis Family history of inflammatory arthritis Early morning stiffness lasting longer than 1 hour and is usually relieved with activity and warmth Swelling in five or more joints Symmetry of the areas affected Bilateral compression tenderness of the metatarsophalangeal joints Rheumatoid factor positivity anti-cyclic citrullinated peptide antibody test positivity Symptoms present for longer than 6 weeks Bony erosions evident on X-rays of the wrists, hands or feet (uncommon in...