Antiplatelets
Introduction Platelets maintain the integrity of the circulation. When platelets are activated, they undergo a series of reactions that are essential for haemostasis, important for healing of damaged blood vessels. Aspirin Low-dose aspirin in chronic use profoundly (>95%) inhibits platelet TXA 2 synthesis by irreversible acetylation of a serine residue in the active site of cyclo-oxygenase I (COX-1). Owing to association with Reye's syndrome , manufacturer advises aspirin-containing preparations should not be given to children under 16 years, unless specifically indicated , e.g. for Kawasaki disease . Contraindications to aspirin include a hypersensitivity to aspirin and major GI intolerance. Dipyridamole Dipyridamole inhibits platelet aggregation by several mechanisms, including Inhibition of phosphodiesterase, Block of adenosine uptake into red cells and Inhibition of TXA2 synthesis It is used in addition aspirin in some patients with stroke or transient ischaemic attack. T...