Stability of IV Injection in Vials
Introduction Unlike outpatient pharmacies, inpatient pharmacies also handle injectable medications. Ampoules are typically single-use containers; once opened, they cannot be resealed, and any remaining medication must be discarded. In contrast, reconstituted powdered drugs can sometimes be stored for a limited time, depending on their chemical and physical stability, which varies between brands. To reduce costs, a reconstituted vial is ideally used for multiple doses. For example, a 1 g vial could provide three 300 mg doses. Below are stability data for common IV vial preparations, including those that are reconstituted. Unless stated otherwise, the stability information refers to the product after reconstitution. For simplicity, this discussion excludes ampoule injections and the stability of reconstituted injections after dilution in various diluents (e.g., normal saline or 5% dextrose). Antimicrobials Acyclovir 250 mg Injection Vacrax - Discard any unused reconstituted solution. Wh...