Rx Note

Introduction Pharmacokinetics - The study of the time course of drug absorption, distribution, metabolism and excretion (ADME) . Pharmacodynamics - The relationship between drug concentration at the site of action and resulting effect, including the time course and intensity of therapeutic and adverse effects. Absorption With intravenous route, all of the administered drug is absorbed. However, if a drug is administered by any other route, it must be absorbed into the blood stream. This process may or may not be 100% efficient. Bioavailability (F) is the fraction of the administered dose which is absorbed into the bloodstream. It only estimates the extent of absorption, not take into consideration the rate of drug absorption. Factors that affect bioavailability include Inherent dissolution and absorption characteristics of the administered chemical form (e.g. salt, ester) The dosage form (e.g. tablet, capsule) The route of administration The stability of the active ingredient in the...